25 Steps to a Faster PC
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14.  Use the Disk Cleanup Utility. 

Pick a time just before you will not be needing your computer for a long stretch, and run the Disk Cleanup Utility.   The process can go very fast or it can hang your computer for hours. 

You can be aggressive about what to delete, although if Disk Cleanup finds Office Setup Files, its generally better to keep them.  This is because if you ever update MS Office via the Microsoft Office Website (http://office.microsoft.com/en-us/officeupdate/default.aspx) its generally handier to use the files on your computer, rather than find and load the Office disks (although finding the setup files is difficult too). 

Also keep setup logs as they are sometimes necessary for software uninstallation. 

There are many freeware tools out there that can help you do the same thing as Disk Cleanup and more, but be careful not to delete uninstall launching executables themselves (as some programs do) as these are obviously necessary for software uninstallation, if you decide to do so later on down the line.